HERC5
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of defense response to virus [IDA]
Gene Ontology Molecular Function
RPL13A
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- cellular response to interferon-gamma [IDA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of formation of translation preinitiation complex [IDA]
- negative regulation of translation [IDA, IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.
This study aims to find differentially expressed ubiquitination-related gene(s) and elucidates their biological significance in breast cancer.Differentially expressed genes were profiled in MCF-7 and MDA-MB-231 cells by using PCR array method. Abnormal expression of HERC5 was studied in the cells and in breast cancer specimens via Quantitative Real-time PCR and western blot. Cell proliferation and cell migration abilities were evaluated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPL13A HERC5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9819 | BioGRID | 3145567 |
Curated By
- BioGRID