TRIM72
Gene Ontology Biological Process
- exocytosis [TAS]
- membrane budding [TAS]
- muscle organ development [IMP]
- muscle system process [IMP]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IGI]
- negative regulation of myotube differentiation [IDA]
- plasma membrane repair [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein homooligomerization [IPI]
- protein ubiquitination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RIPK1
Gene Ontology Biological Process
- T cell apoptotic process [IMP]
- amyloid fibril formation [ISO]
- apoptotic process [ISO]
- cellular protein catabolic process [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to tumor necrosis factor [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- necroptotic process [IGI, ISO]
- necroptotic signaling pathway [IMP, ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- peptidyl-serine autophosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of JNK cascade [IMP, ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of necroptotic process [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of programmed cell death [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transferase activity [IGI]
- positive regulation of tumor necrosis factor production [ISO]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- regulation of ATP:ADP antiporter activity [ISO]
- regulation of reactive oxygen species metabolic process [IMP]
- response to tumor necrosis factor [ISO]
- ripoptosome assembly [ISO]
- ripoptosome assembly involved in necroptotic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury.
While reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against ischemia-reperfusion (I/R) injury. Thus, the precise role of ROS following cardiac injury remains to be fully elucidated.We investigated the role of mitsugumin 53 (MG53) in regulating necroptosis ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID