TRIM72
Gene Ontology Biological Process
- exocytosis [TAS]
- membrane budding [TAS]
- muscle organ development [IMP]
- muscle system process [IMP]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IGI]
- negative regulation of myotube differentiation [IDA]
- plasma membrane repair [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein homooligomerization [IPI]
- protein ubiquitination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RIPK3
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IDA]
- NIK/NF-kappaB signaling [IDA]
- T cell differentiation in thymus [IGI]
- T cell homeostasis [IGI]
- activation of protein kinase activity [ISO]
- amyloid fibril formation [ISO]
- lymph node development [IGI]
- necroptotic process [IGI, IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [IDA]
- positive regulation of ligase activity [IDA]
- positive regulation of necroptotic process [IMP, ISO]
- positive regulation of oxidoreductase activity [IDA]
- positive regulation of phosphatase activity [ISO]
- positive regulation of protein deacetylation [IGI]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of transferase activity [IGI]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- protein phosphorylation [IDA]
- regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [IGI]
- regulation of T cell mediated cytotoxicity [IGI]
- regulation of activated T cell proliferation [IGI]
- regulation of activation-induced cell death of T cells [IGI]
- regulation of adaptive immune response [IGI]
- regulation of interferon-gamma production [IGI]
- regulation of reactive oxygen species metabolic process [IMP]
- signal transduction by phosphorylation [IDA]
- spleen development [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury.
While reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against ischemia-reperfusion (I/R) injury. Thus, the precise role of ROS following cardiac injury remains to be fully elucidated.We investigated the role of mitsugumin 53 (MG53) in regulating necroptosis ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID