USP47
Gene Ontology Biological Process
- base-excision repair [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [ISO]
- monoubiquitinated protein deubiquitination [ISO]
- negative regulation of G2/M transition of mitotic cell cycle [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of transcription, DNA-templated [IBA, ISO]
- positive regulation of cell growth [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA]
- regulation of apoptotic process [IBA]
- regulation of proteasomal protein catabolic process [IBA]
- response to drug [ISO]
Gene Ontology Molecular Function
NLRP3
Gene Ontology Biological Process
- NLRP3 inflammasome complex assembly [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cellular response to lipopolysaccharide [ISO]
- defense response to virus [ISO]
- inflammatory response [ISO]
- interleukin-1 beta production [ISO]
- interleukin-1 secretion [ISO]
- interleukin-18 production [ISO]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of acute inflammatory response [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of interleukin-1 beta secretion [ISO]
- regulation of inflammatory response [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LncRNA ZNF883-Mediated NLRP3 Inflammasome Activation and Epilepsy Development Involve USP47 Upregulation.
The goal of this study was to characterize the mechanisms of long noncoding RNA (lncRNA) ZNF883 regulating NOD-like receptor 3 (NLRP3) inflammasome activation in epilepsy (EP). Rat and cellular EP models were established using pilocarpine and magnesium-free extracellular fluid, respectively, to detect the differential expression of ZNF883, microRNA (miR)-138-5p, ubiquitin-specific peptidase 47 (USP47), and NLRP3. The pathology of the hippocampal ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NLRP3 USP47 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID