NEURL2
MYH6
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- adult heart development [IMP]
- atrial cardiac muscle tissue morphogenesis [IMP]
- cardiac muscle fiber development [ISS]
- in utero embryonic development [ISS]
- muscle contraction [IDA]
- muscle filament sliding [IMP, TAS]
- myofibril assembly [ISS]
- regulation of ATPase activity [ISS]
- regulation of blood pressure [ISS]
- regulation of heart contraction [ISS]
- regulation of heart rate [IDA]
- regulation of the force of heart contraction [IDA, ISS]
- sarcomere organization [ISS]
- striated muscle contraction [IMP, ISS]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- visceral muscle development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Biophysical and functional study of CRL5Ozz, a muscle specific ubiquitin ligase complex.
Ozz, a member of the SOCS-box family of proteins, is the substrate-binding component of CRL5Ozz, a muscle-specific Cullin-RING ubiquitin ligase complex composed of Elongin B/C, Cullin 5 and Rbx1. CRL5Ozz targets for proteasomal degradation selected pools of substrates, including sarcolemma-associated ?-catenin, sarcomeric MyHCemb and Alix/PDCD6IP, which all interact with the actin cytoskeleton. Ubiquitination and degradation of these substrates are required ... [more]
Throughput
- Low Throughput
Additional Notes
- E2: UbcH5b
Curated By
- BioGRID