BAIT
ATP1A1
RP4-655J12.1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (14)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- cardiac muscle contraction [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular potassium ion homeostasis [IDA]
- cellular response to steroid hormone stimulus [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- potassium ion import [IDA]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [TAS]
- response to glycoside [IDA]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DDX3X
CAP-Rf, DBX, DDX14, DDX3, HLP2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
GO Process (29)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- DNA duplex unwinding [IDA]
- RNA secondary structure unwinding [IDA]
- cellular response to arsenic-containing substance [IDA]
- cellular response to osmotic stress [IDA]
- chromosome segregation [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- innate immune response [IMP]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway [IMP]
- mature ribosome assembly [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of protein complex assembly [IDA]
- negative regulation of translation [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of chemokine (C-C motif) ligand 5 production [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of interferon-beta production [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of translation [IDA]
- positive regulation of translational initiation [IMP]
- positive regulation of viral genome replication [IMP]
- response to virus [IDA]
- stress granule assembly [IDA]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
- ATP-dependent DNA helicase activity [IDA]
- ATP-dependent RNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- RNA binding [IDA]
- RNA stem-loop binding [IDA]
- eukaryotic initiation factor 4E binding [IDA]
- mRNA 5'-UTR binding [IDA]
- poly(A) RNA binding [IDA]
- poly(A) binding [IDA]
- protein binding [IPI]
- ribosomal small subunit binding [IDA]
- transcription factor binding [IDA]
- translation initiation factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of different proteins binding to Na, K-ATPase ?1 in LPS-induced ARDS cell model by proteomic analysis.
Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pulmonary epithelium and impaired Na, K-ATPase function, especially Na, K-ATPase ?1 subunit. Up until now, the pathogenic mechanism at the level of protein during lipopolysaccharide- (LPS-) induced ARDS remains unclear.Using an unbiased, discovery ... [more]
Proteome Sci Jun. 09, 2022; 20(1);10 [Pubmed: 35681168]
Throughput
- High Throughput
Curated By
- BioGRID