BAIT
ATP1A1
RP4-655J12.1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (14)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- cardiac muscle contraction [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular potassium ion homeostasis [IDA]
- cellular response to steroid hormone stimulus [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- potassium ion import [IDA]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [TAS]
- response to glycoside [IDA]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ASPH
AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin
aspartate beta-hydroxylase
GO Process (17)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IDA]
- activation of store-operated calcium channel activity [IDA]
- calcium ion transmembrane transport [IDA]
- cellular response to calcium ion [IDA]
- detection of calcium ion [TAS]
- muscle contraction [TAS]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of intracellular protein transport [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- response to ATP [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [TAS]
- cortical endoplasmic reticulum [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [NAS]
- integral component of endoplasmic reticulum membrane [IDA]
- junctional sarcoplasmic reticulum membrane [TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of different proteins binding to Na, K-ATPase ?1 in LPS-induced ARDS cell model by proteomic analysis.
Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pulmonary epithelium and impaired Na, K-ATPase function, especially Na, K-ATPase ?1 subunit. Up until now, the pathogenic mechanism at the level of protein during lipopolysaccharide- (LPS-) induced ARDS remains unclear.Using an unbiased, discovery ... [more]
Proteome Sci Jun. 09, 2022; 20(1);10 [Pubmed: 35681168]
Throughput
- High Throughput
Curated By
- BioGRID