BAIT
GATA4
GATA binding protein 4
GO Process (61)
GO Function (17)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- SMAD protein signal transduction [ISO]
- Sertoli cell differentiation [ISO]
- atrial septum morphogenesis [ISO]
- atrial septum primum morphogenesis [ISO]
- atrial septum secundum morphogenesis [ISO]
- atrioventricular canal development [ISO]
- atrioventricular valve formation [ISO]
- atrioventricular valve morphogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- cardiac muscle cell differentiation [IEP, ISO]
- cardiac muscle hypertrophy in response to stress [ISO]
- cardiac muscle tissue development [ISO]
- cardiac right ventricle morphogenesis [ISO]
- cardiac septum development [ISO]
- cell growth involved in cardiac muscle cell development [IDA]
- cell-cell signaling [ISO]
- cellular response to follicle-stimulating hormone stimulus [ISO]
- cellular response to glucose stimulus [IEP]
- cellular response to gonadotropin stimulus [ISO]
- embryonic digestive tract morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic heart tube anterior/posterior pattern specification [ISO]
- embryonic heart tube development [ISO]
- embryonic morphogenesis [ISO]
- endocardial cushion development [ISO]
- endoderm formation [ISO]
- epithelial cell fate commitment [ISO]
- gastrulation with mouth forming second [ISO]
- heart development [ISO, TAS]
- heart looping [ISO]
- heart morphogenesis [ISO]
- in utero embryonic development [ISO]
- intestinal epithelial cell differentiation [ISO]
- lung lobe formation [ISO]
- male gonad development [ISO]
- negative regulation of autophagy [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of angiogenesis [ISO]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle cell proliferation [ISO]
- regulation of gene expression [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to drug [ISO]
- response to estrogen [ISO]
- response to mechanical stimulus [IDA]
- response to retinoic acid [ISO]
- response to vitamin A [IEP]
- seminiferous tubule development [ISO]
- signal transduction involved in regulation of gene expression [ISO]
- spermatogenesis [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transdifferentiation [IMP]
- tube morphogenesis [ISO]
- ventricular cardiac muscle tissue development [ISO]
- ventricular septum development [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NFAT protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- activating transcription factor binding [IPI]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [IDA]
- sequence-specific DNA binding [IMP, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [IDA, IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- zinc ion binding [TAS]
- DNA binding [IDA, ISO]
- NFAT protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- activating transcription factor binding [IPI]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- enhancer sequence-specific DNA binding [IDA]
- sequence-specific DNA binding [IMP, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [IDA, IPI, ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
GO Process (0)
GO Function (3)
GO Component (10)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4.
Although the pro-hypertrophic role of GATA binding protein 4 (GATA4) during cardiac hypertrophy has been well established, the negative regulatory mechanism to counteract its hyperactivation remains elusive. We hypothesized that the hyperactivation of GATA4 could be a result of loss of interaction between GATA4 with specific suppressors. Using high throughput mass spectrometry technology, we carried out a proteomic screen for ... [more]
J Mol Cell Cardiol Aug. 01, 2022; 169();96-110 [Pubmed: 35659652]
Throughput
- High Throughput
Curated By
- BioGRID