BAIT
BHLHE40
Bhlhb2, Dec1, SHARP-2, Sharp2, Stra13, Stra14
basic helix-loop-helix family, member e40
GO Process (11)
GO Function (13)
GO Component (4)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISO]
- circadian rhythm [IEP]
- entrainment of circadian clock [IDA]
- entrainment of circadian clock by photoperiod [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- nervous system development [NAS]
- regulation of neuronal synaptic plasticity [IEP, NAS]
- response to light stimulus [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- E-box binding [ISO, ISS]
- MRF binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- transcription corepressor activity [ISO, ISS]
- DNA binding [ISO]
- E-box binding [ISO, ISS]
- MRF binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [ISO]
- bHLH transcription factor binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- transcription corepressor activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SEC31A
Sec31l1, VAP1
SEC31 homolog A (S. cerevisiae)
GO Process (1)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4.
Although the pro-hypertrophic role of GATA binding protein 4 (GATA4) during cardiac hypertrophy has been well established, the negative regulatory mechanism to counteract its hyperactivation remains elusive. We hypothesized that the hyperactivation of GATA4 could be a result of loss of interaction between GATA4 with specific suppressors. Using high throughput mass spectrometry technology, we carried out a proteomic screen for ... [more]
J Mol Cell Cardiol Aug. 01, 2022; 169();96-110 [Pubmed: 35659652]
Throughput
- High Throughput
Curated By
- BioGRID