BAIT
USP40
ubiquitin specific peptidase 40
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RPS18
D6S218E, HKE3, KE-3, KE3, S18, DADB-159G18.1
ribosomal protein S18
GO Process (14)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- ribosome biogenesis [IBA]
- translation [IBA, IC, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.
Podocyte damage is a major pathological lesion leading to focal segmental glomerulosclerosis (FSGS). Podocytes damaged by cellular stress undergo hypertrophy to compensate for podocytopenia. It is known that cyclin-dependent kinase inhibitors induced by p53 ensure podocytes hypertrophy; however, its precise mechanism remains to be further investigated. In this study, we found that ubiquitin specific protease 40 (USP40) is a novel ... [more]
Biochem Biophys Res Commun Dec. 23, 2021; 614();198-206 [Pubmed: 35605301]
Throughput
- High Throughput|Low Throughput
Curated By
- BioGRID