Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.

Takahashi S, Fukuhara D, Kimura T, Fukutomi T, Tanaka E, Mikami N, Hada I, Takematsu H, Nishibori Y, Akimoto Y, Kiyonari H, Abe T, Huber O, Yan K

Podocyte damage is a major pathological lesion leading to focal segmental glomerulosclerosis (FSGS). Podocytes damaged by cellular stress undergo hypertrophy to compensate for podocytopenia. It is known that cyclin-dependent kinase inhibitors induced by p53 ensure podocytes hypertrophy; however, its precise mechanism remains to be further investigated. In this study, we found that ubiquitin specific protease 40 (USP40) is a novel ... [more]

Biochem Biophys Res Commun Dec. 23, 2021; 614();198-206 [Pubmed: 35605301]

Throughput

High Throughput|Low Throughput

Curated By

BioGRID

Interaction Summary

USP40

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IBA]ubiquitin thiolesterase activity [IBA]ubiquitin-specific protease activity [IBA]

Gene Ontology Cellular Component

C1QA