BAIT
DCK
deoxycytidine kinase
GO Process (9)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- deoxyribonucleoside monophosphate biosynthetic process [IDA, TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide biosynthetic process [EXP]
- purine nucleobase metabolic process [TAS]
- purine-containing compound salvage [TAS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside salvage [TAS]
- pyrimidine nucleotide metabolic process [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
EEF1D
EF-1D, EF1D, FP1047, UNQ601
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
GO Process (6)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.
Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions. dCK is activated in response to DNA damage; however, how it functions in the DNA damage response is largely unknown. Here, we report that dCK is required for the G2/M checkpoint in response ... [more]
Nucleic Acids Res Oct. 01, 2012; 40(19);9621-32 [Pubmed: 22850745]
Throughput
- Low Throughput
Curated By
- BioGRID