BAIT
PAT1
MRT1, L000001183, L000003214, YCR077C
Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation
GO Process (7)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- CENP-A containing chromatin organization [IMP]
- chromosome segregation [IMP]
- cytoplasmic mRNA processing body assembly [IGI, IMP]
- deadenylation-dependent decapping of nuclear-transcribed mRNA [IMP, IPI]
- formation of translation preinitiation complex [IMP]
- negative regulation of translational initiation [IDA, IMP]
- regulation of translational initiation [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
GIM3
PFD4, L000004369, YNL153C
Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae.
The Processing-body is a conserved membraneless organelle that has been implicated in the storage and/or decay of mRNAs. Although Processing-bodies have been shown to be induced by a variety of conditions, the mechanisms controlling their assembly and their precise physiological roles in eukaryotic cells are still being worked out. In this study, we find that a distinct subtype of Processing-body ... [more]
Genetics Aug. 30, 2022; 222(1); [Pubmed: 35876801]
Throughput
- Low Throughput
Ontology Terms
- protein/peptide accumulation (APO:0000149)
Additional Notes
- deletion of pfd genes partially suppresses the P-body formation defect seen in pat1 mutants
Curated By
- BioGRID