BAIT
ORF6
SARS-CoV2 ORF6, SARS-CoV-2 ORF6, 6, NS6_SARS2, PRO_0000449653, GU280_gp06
Non-structural protein 6
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY
RPS5
S5
ribosomal protein S5
GO Process (14)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- regulation of translational fidelity [IGI]
- translation [IC, IGI, NAS, TAS]
- translational elongation [TAS]
- translational initiation [IC, TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.
SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the SARS-CoV-2 pathogenic proteins that through host interactions cause the cellular damages underlying COVID-19 symptomatology.We examined each of the individual SARS-CoV-2 proteins for their cytotoxicity in HEK 293 T cells and their subcellular localization in COS-7 cells. We also ... [more]
Cell Biosci Mar. 25, 2021; 11(1);58 [Pubmed: 33766124]
Throughput
- High Throughput
Additional Notes
- Gene listed in GO enrichment analysis in Table S2
Curated By
- BioGRID