BAIT
MECP2
1500041B07Rik, D630021H01Rik, Mbd5, WBP10, RP23-252M19.8
methyl CpG binding protein 2
GO Process (58)
GO Function (17)
GO Component (9)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- behavioral fear response [IMP]
- brain development [IMP]
- cardiolipin metabolic process [IMP]
- catecholamine secretion [IMP]
- cellular biogenic amine metabolic process [IMP]
- cerebellum development [IMP]
- chromatin silencing [IMP]
- dendrite development [IMP]
- embryo development [IMP]
- glucocorticoid metabolic process [IMP]
- glutamine metabolic process [IMP]
- histone acetylation [IMP]
- histone methylation [IMP]
- inositol metabolic process [IMP]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- mitochondrial electron transport, ubiquinol to cytochrome c [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of histone acetylation [IMP]
- negative regulation of histone methylation [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- neurological system process involved in regulation of systemic arterial blood pressure [IMP]
- neuromuscular process [IMP]
- neuromuscular process controlling posture [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- pathogenesis [IMP]
- phosphatidylcholine metabolic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of synapse assembly [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IMP]
- proprioception [IMP]
- protein localization [IMP]
- regulation of DNA methylation [ISO]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of gene expression [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IMP]
- regulation of synaptic plasticity [IMP]
- regulation of transcription, DNA-templated [IMP]
- respiratory gaseous exchange [IMP]
- response to hypoxia [IMP]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP]
- ventricular system development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RPS11
ribosomal protein S11
GO Process (2)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.
MeCP2 is associated with Rett syndrome (RTT), MECP2 duplication syndrome, and a number of conditions with isolated features of these diseases, including autism, intellectual disability, and motor dysfunction. MeCP2 is known to broadly bind methylated DNA, but the precise molecular mechanism driving disease pathogenesis remains to be determined. Using proximity-dependent biotinylation (BioID), we identified a transcription factor 20 (TCF20) complex ... [more]
Proc Natl Acad Sci U S A Jan. 25, 2022; 119(4); [Pubmed: 35074918]
Throughput
- Low Throughput
Additional Notes
- BioID
Curated By
- BioGRID