BAIT
USP53
ubiquitin specific peptidase 53
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
BAZ1B
WBSCR10, WBSCR9, WSTF
bromodomain adjacent to zinc finger domain, 1B
GO Process (8)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- chromatin-mediated maintenance of transcription [ISS]
- double-strand break repair [ISS]
- heart morphogenesis [ISS]
- histone phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- regulation of transcription, DNA-templated [ISS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.
Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly incurable and has been recognized as the third leading cause of cancer-related deaths worldwide. As a deubiquitinating enzyme, the antitumor effect of ubiquitin-specific peptidase 53 (USP53) has been demonstrated on few malignancies. In this study, we investigated the potential antitumor role of USP53 in HCC. The results showed that ... [more]
Oncogenesis Jun. 02, 2022; 11(1);31 [Pubmed: 35654790]
Throughput
- Low Throughput
Curated By
- BioGRID