BAIT

ORF57

HHV8GK18_gp61
post-transcriptional regulator
GO Process (0)
GO Function (0)
GO Component (0)
Human Herpesvirus 8
PREY

ATAD3A

RP5-832C2.1
ATPase family, AAA domain containing 3A
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, Wang KH, Inagaki T, Chuang F, Davis RR, Tepper CG, Nakano K, Izumiya C, Shimoda M, Nakajima KI, Merleev A, Zheng ZM, Campbell M, Izumiya Y

Kaposi sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the cell nucleus, but where KSHV episomal genomes are tethered and the mechanisms underlying KSHV lytic reactivation are unclear. Here, we study the nuclear microenvironment of KSHV episomes and show that the KSHV latency-lytic replication switch is regulated via viral long non-coding (lnc)RNA-CHD4 (chromodomain helicase DNA binding protein 4) interaction. KSHV ... [more]

Cell Rep Dec. 10, 2021; 39(6);110788 [Pubmed: 35545047]

Throughput

  • High Throughput

Curated By

  • BioGRID