BAIT
RB1CC1
2900055E04Rik, 5930404L04Rik, Cc1, FIP200, LaXp180
RB1-inducible coiled-coil 1
GO Process (9)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- JNK cascade [IGI]
- autophagic vacuole assembly [IMP]
- heart development [IMP]
- liver development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of cell size [IMP]
- positive regulation of protein phosphorylation [IMP]
- regulation of autophagy [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HADHA
C77020, Mtpa
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
GO Process (4)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and?pathological stress. Autophagy initiation converges on the FIP200-ATG13-ULK1 complex wherein the serine/threonine kinase ULK1 plays a central role. Here, we reveal that the E3 ubiquitin ligase?TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex. TRIM27 directly polyubiquitinates ULK1 at K568 and K571 ... [more]
EMBO J Dec. 18, 2021; 41(14);e109777 [Pubmed: 35670107]
Throughput
- Low Throughput
Curated By
- BioGRID