BAIT
RB1CC1
2900055E04Rik, 5930404L04Rik, Cc1, FIP200, LaXp180
RB1-inducible coiled-coil 1
GO Process (9)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- JNK cascade [IGI]
- autophagic vacuole assembly [IMP]
- heart development [IMP]
- liver development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of cell size [IMP]
- positive regulation of protein phosphorylation [IMP]
- regulation of autophagy [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and?pathological stress. Autophagy initiation converges on the FIP200-ATG13-ULK1 complex wherein the serine/threonine kinase ULK1 plays a central role. Here, we reveal that the E3 ubiquitin ligase?TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex. TRIM27 directly polyubiquitinates ULK1 at K568 and K571 ... [more]
EMBO J Dec. 18, 2021; 41(14);e109777 [Pubmed: 35670107]
Throughput
- Low Throughput
Curated By
- BioGRID