BAIT
TRIM27
AW538890, Gm19403, Rfp
tripartite motif-containing 27
GO Process (17)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [ISO]
- innate immune response [IDA, ISO]
- interferon-gamma secretion [ISO]
- negative regulation of adaptive immune response [ISO]
- negative regulation of calcium ion import [ISO]
- negative regulation of gene expression, epigenetic [ISO]
- negative regulation of interleukin-2 secretion [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of tumor necrosis factor production [ISO]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA, ISO]
- positive regulation of actin nucleation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein K63-linked ubiquitination [ISO]
- protein trimerization [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CKAP4
5630400A09Rik, CLIMP-63, P63
cytoskeleton-associated protein 4
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and?pathological stress. Autophagy initiation converges on the FIP200-ATG13-ULK1 complex wherein the serine/threonine kinase ULK1 plays a central role. Here, we reveal that the E3 ubiquitin ligase?TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex. TRIM27 directly polyubiquitinates ULK1 at K568 and K571 ... [more]
EMBO J Dec. 18, 2021; 41(14);e109777 [Pubmed: 35670107]
Throughput
- Low Throughput
Curated By
- BioGRID