BAIT
MAP1B
FUTSCH, MAP5, PPP1R102
microtubule-associated protein 1B
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP5B
ATPMB, ATPSB, HEL-S-271
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
GO Process (11)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [IMP]
- ATP catabolic process [IDA]
- angiogenesis [IMP]
- cellular metabolic process [TAS]
- generation of precursor metabolites and energy [NAS]
- mitochondrial ATP synthesis coupled proton transport [IC, TAS]
- osteoblast differentiation [IDA]
- proton transport [IMP]
- regulation of intracellular pH [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- mitochondrial matrix [NAS, TAS]
- mitochondrial membrane [IDA]
- mitochondrial nucleoid [IDA]
- mitochondrial proton-transporting ATP synthase complex [IDA]
- mitochondrial proton-transporting ATP synthase, catalytic core [NAS]
- mitochondrion [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.
Ubiquilin-2 (UBQLN2) is a ubiquitin-binding protein that shuttles ubiquitinated proteins to proteasomal and autophagic degradation. UBQLN2 mutations are genetically linked to the neurodegenerative disorders amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). However, it remains elusive how UBQLN2 mutations cause ALS/FTD. Here, we systematically examined proteomic and transcriptomic changes in patient-derived lymphoblasts and CRISPR/Cas9-engineered HeLa cells carrying ALS/FTD UBQLN2 mutations. This ... [more]
Life Sci Alliance Dec. 01, 2021; 5(11); [Pubmed: 35777956]
Throughput
- Low Throughput
Curated By
- BioGRID