BAIT
OVOL2
EUROIMAGE566589, ZNF339
ovo-like zinc finger 2
GO Process (7)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of epithelial to mesenchymal transition [ISS]
- negative regulation of keratinocyte differentiation [IMP]
- negative regulation of transcription by competitive promoter binding [IDA]
- regulation of cell cycle [IMP]
- regulation of keratinocyte proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
NME2
NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF
NME/NM23 nucleoside diphosphate kinase 2
GO Process (12)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- cell adhesion [TAS]
- integrin-mediated signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleoside triphosphate biosynthetic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermis development [IMP]
- regulation of transcription, DNA-templated [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays a critical role in cancer cell growth and metastasis; however, direct inhibition of the Warburg effect remains largely unknown. Herein, the transcription factor OVO-like zinc finger 2 (OVOL2) is demonstrated to directly repress the expression of several glycolytic genes, blocking the Warburg effect and breast tumor growth and metastasis in vitro and ... [more]
Adv Sci (Weinh) Sep. 01, 2022; 9(27);e2200705 [Pubmed: 35896951]
Throughput
- High Throughput
Curated By
- BioGRID