BAIT
OVOL2
EUROIMAGE566589, ZNF339
ovo-like zinc finger 2
GO Process (7)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of epithelial to mesenchymal transition [ISS]
- negative regulation of keratinocyte differentiation [IMP]
- negative regulation of transcription by competitive promoter binding [IDA]
- regulation of cell cycle [IMP]
- regulation of keratinocyte proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
ARF6
ADP-ribosylation factor 6
GO Process (14)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cell adhesion [TAS]
- cellular component movement [TAS]
- cortical actin cytoskeleton organization [IMP]
- negative regulation of receptor-mediated endocytosis [TAS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- protein localization to cell surface [ISS]
- protein localization to endosome [IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of dendritic spine development [ISS]
- regulation of filopodium assembly [IDA]
- ruffle organization [IDA]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays a critical role in cancer cell growth and metastasis; however, direct inhibition of the Warburg effect remains largely unknown. Herein, the transcription factor OVO-like zinc finger 2 (OVOL2) is demonstrated to directly repress the expression of several glycolytic genes, blocking the Warburg effect and breast tumor growth and metastasis in vitro and ... [more]
Adv Sci (Weinh) Sep. 01, 2022; 9(27);e2200705 [Pubmed: 35896951]
Throughput
- High Throughput
Curated By
- BioGRID