BAIT
LATS1
WARTS, wts
large tumor suppressor kinase 1
GO Process (11)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cytoplasmic sequestering of protein [IMP]
- hippo signaling [IDA, TAS]
- hormone-mediated signaling pathway [ISS]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of actin filament polymerization [IDA]
- regulation of protein complex assembly [IMP]
- sister chromatid segregation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
E2F7
E2F transcription factor 7
GO Process (13)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- chorionic trophoblast cell differentiation [ISS]
- hepatocyte differentiation [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytokinesis [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IDA]
- placenta development [ISS]
- positive regulation of DNA endoreduplication [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- sprouting angiogenesis [IMP]
- trophoblast giant cell differentiation [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.
Metastatic malignant melanoma is the deadliest skin cancer, and it is characterised by its high resistance to apoptosis. The main melanoma driving mutations are part of ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK mutations. Increasing evidence shows that the MST2/Hippo pathway is also deregulated in melanoma. While mutations are rare, MST2/Hippo ... [more]
Cell Death Dis Aug. 08, 2022; 13(8);692 [Pubmed: 35941108]
Throughput
- Low Throughput
Curated By
- BioGRID