BAIT
MECOM
AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, hCG_1640438
MDS1 and EVI1 complex locus
GO Process (8)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- hematopoietic stem cell proliferation [ISS]
- negative regulation of JNK cascade [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell cycle [IDA]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP1R9A
NRB1, NRBI, Neurabin-I
protein phosphatase 1, regulatory subunit 9A
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.
Ecotropic viral integration site-1 (EVI1) is an oncogenic zinc finger transcription factor whose expression is frequently up-regulated in myeloid leukemia and epithelial cancers. To better understand the mechanisms underlying EVI1-associated disease, we sought to define the EVI1 interactome in cancer cells. By using stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics, we could confidently assign 78 ... [more]
Proc Natl Acad Sci U S A Jul. 30, 2013; 110(31);E2885-94 [Pubmed: 23858473]
Throughput
- Low Throughput
Curated By
- BioGRID