BAIT
TAP2
ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, DAAP-57C1.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
GO Process (12)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I [IDA, IMP]
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [IBA]
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [IBA]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytosol to ER transport [IMP]
- intracellular transport of viral protein in host cell [IMP]
- peptide antigen transport [IDA, IMP]
- positive regulation of antigen processing and presentation of peptide antigen via MHC class I [IBA]
- transmembrane transport [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP1A1
RP4-655J12.1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (14)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- cardiac muscle contraction [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular potassium ion homeostasis [IDA]
- cellular response to steroid hormone stimulus [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- potassium ion import [IDA]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [TAS]
- response to glycoside [IDA]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.
Membrane protein clients of endoplasmic reticulum (ER)-associated degradation must be retrotranslocated from the ER membrane by the AAA-ATPase p97 for proteasomal degradation. Before direct engagement with p97, client transmembrane domains (TMDs) that have partially or fully crossed the membrane must be constantly shielded to avoid non-native interactions. How client TMDs are seamlessly escorted from the membrane to p97 is unknown. ... [more]
Mol Cell Dec. 15, 2021; 82(18);3453-3467.e14 [Pubmed: 35961308]
Throughput
- High Throughput
Curated By
- BioGRID