BAIT

TMUB1

C7orf21, DULP, SB144
transmembrane and ubiquitin-like domain containing 1
UPS Project
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens
PREY

CYP51A1

CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
cytochrome P450, family 51, subfamily A, polypeptide 1
Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.

Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y, Zhang ZR

Membrane protein clients of endoplasmic reticulum (ER)-associated degradation must be retrotranslocated from the ER membrane by the AAA-ATPase p97 for proteasomal degradation. Before direct engagement with p97, client transmembrane domains (TMDs) that have partially or fully crossed the membrane must be constantly shielded to avoid non-native interactions. How client TMDs are seamlessly escorted from the membrane to p97 is unknown. ... [more]

Mol Cell Dec. 15, 2021; 82(18);3453-3467.e14 [Pubmed: 35961308]

Throughput

  • Low Throughput

Curated By

  • BioGRID