BAIT
RNF8
hRNF8
ring finger protein 8, E3 ubiquitin protein ligase
GO Process (17)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IDA]
- double-strand break repair via nonhomologous end joining [ISS]
- histone H2A K63-linked ubiquitination [IDA, IMP]
- histone H2A ubiquitination [IDA]
- histone H2B ubiquitination [ISS]
- histone exchange [ISS]
- interstrand cross-link repair [TAS]
- isotype switching [ISS]
- negative regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of DNA repair [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- response to ionizing radiation [IDA]
- spermatid development [ISS]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF1A1
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2
eukaryotic translation elongation factor 1 alpha 1
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A functional reference map of the RNF8 interactome in cancer.
RNF8 is an E3 ligase identified as a critical DNA damage-responsive protein. Recently, multiple reports have shown that RNF8 could be used as an important therapeutic target for cancer chemo/radiotherapy. However, the understanding of RNF8 remains limited due to the lack of its interactome reference map and comprehensive analysis of RNF8 in diverse cancers, which underscores the need to map ... [more]
Biol Direct Dec. 13, 2021; 17(1);17 [Pubmed: 35831895]
Throughput
- High Throughput
Curated By
- BioGRID