BAIT
ACVRL1
AI115505, AI427544, Acvrlk1, Alk1
activin A receptor, type II-like 1
GO Process (42)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- activin receptor signaling pathway [ISO]
- angiogenesis [IMP, ISO]
- artery development [IMP]
- blood circulation [ISO]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- cellular response to BMP stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- endothelial cell activation [TAS]
- endothelial tube morphogenesis [ISO]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP, ISO]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell adhesion [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell differentiation [IDA]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of focal adhesion assembly [ISO]
- positive regulation of BMP signaling pathway [IDA, ISO]
- positive regulation of angiogenesis [IGI]
- positive regulation of endothelial cell differentiation [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [ISO]
- regulation of blood pressure [ISO]
- regulation of transcription, DNA-templated [ISO]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- signal transduction by phosphorylation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- venous blood vessel development [IMP]
- wound healing, spreading of epidermal cells [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RAB3C
2700062I01Rik, 3110015B08Rik, 3110037E15Rik, AI850886
RAB3C, member RAS oncogene family
GO Process (8)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Mol Cell Proteomics Feb. 01, 2014; 13(2);489-502 [Pubmed: 24319055]
Throughput
- Low Throughput
Additional Notes
- Lumier screen
Curated By
- BioGRID