ACVRL1
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- activin receptor signaling pathway [ISO]
- angiogenesis [IMP, ISO]
- artery development [IMP]
- blood circulation [ISO]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- cellular response to BMP stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- endothelial cell activation [TAS]
- endothelial tube morphogenesis [ISO]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP, ISO]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell adhesion [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell differentiation [IDA]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of focal adhesion assembly [ISO]
- positive regulation of BMP signaling pathway [IDA, ISO]
- positive regulation of angiogenesis [IGI]
- positive regulation of endothelial cell differentiation [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [ISO]
- regulation of blood pressure [ISO]
- regulation of transcription, DNA-templated [ISO]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- signal transduction by phosphorylation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- venous blood vessel development [IMP]
- wound healing, spreading of epidermal cells [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
Gene Ontology Cellular Component
PPP1CA
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Throughput
- Low Throughput
Additional Notes
- Lumier screen
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACVRL1 PPP1CA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID