BAIT
ENG
AI528660, AI662476, CD105, Endo, S-endoglin, RP23-17P12.4
endoglin
GO Process (38)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- angiogenesis [IMP]
- artery morphogenesis [IMP]
- cell chemotaxis [ISO]
- cell migration [ISO]
- cell migration involved in endocardial cushion formation [IMP]
- cell motility [ISO]
- central nervous system vasculogenesis [ISO]
- detection of hypoxia [ISO]
- extracellular matrix constituent secretion [ISO]
- extracellular matrix disassembly [ISO]
- heart development [IMP]
- heart looping [IMP]
- intracellular signal transduction [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of nitric-oxide synthase activity [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of protein autophosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- patterning of blood vessels [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [IGI, TAS]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of systemic arterial blood pressure [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [ISO]
- regulation of transcription, DNA-templated [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO, TAS]
- response to hypoxia [ISO]
- smooth muscle tissue development [IMP]
- transforming growth factor beta receptor signaling pathway [IC]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vasculogenesis [IMP, ISO]
- venous blood vessel morphogenesis [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- galactose binding [ISO]
- glycosaminoglycan binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IPI, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor, cytoplasmic mediator activity [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [ISO]
- galactose binding [ISO]
- glycosaminoglycan binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IPI, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor, cytoplasmic mediator activity [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
EPS8L1
2310051G19Rik, 4632407K17Rik, AW060268, DRC3, EPS8R1
EPS8-like 1
GO Process (6)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Mol Cell Proteomics Feb. 01, 2014; 13(2);489-502 [Pubmed: 24319055]
Throughput
- Low Throughput
Additional Notes
- Lumier screen
Curated By
- BioGRID