BAIT
TGFBR2
1110020H15Rik, AU042018, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
transforming growth factor, beta receptor II
GO Process (50)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- activation of protein kinase activity [IDA]
- apoptotic process [ISO]
- brain development [IMP]
- bronchus development [IMP]
- bronchus morphogenesis [IMP]
- cartilage development [IMP]
- common-partner SMAD protein phosphorylation [ISO]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic hemopoiesis [IMP]
- gastrulation [IMP]
- growth plate cartilage chondrocyte growth [IMP]
- growth plate cartilage development [IGI]
- heart development [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- lens fiber cell apoptotic process [IDA]
- lung development [IMP]
- lung lobe morphogenesis [IMP]
- lung morphogenesis [IMP]
- mammary gland morphogenesis [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- organ morphogenesis [ISO]
- palate development [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- patterning of blood vessels [IMP]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of B cell tolerance induction [IMP]
- positive regulation of NK T cell differentiation [IMP]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of angiogenesis [IGI]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of tolerance induction to self antigen [IMP]
- protein phosphorylation [IGI, ISO, TAS]
- receptor-mediated endocytosis [ISO]
- regulation of cell proliferation [IMP]
- regulation of gene expression [IMP]
- response to cholesterol [IDA, ISO]
- response to drug [ISO]
- smoothened signaling pathway [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- transforming growth factor beta receptor signaling pathway [IMP, ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- SMAD binding [IDA, ISO]
- glycosaminoglycan binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type II [ISO]
- transforming growth factor beta-activated receptor activity [IGI, ISO]
- transmembrane receptor protein serine/threonine kinase activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type III transforming growth factor beta receptor binding [ISO]
- SMAD binding [IDA, ISO]
- glycosaminoglycan binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type II [ISO]
- transforming growth factor beta-activated receptor activity [IGI, ISO]
- transmembrane receptor protein serine/threonine kinase activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type III transforming growth factor beta receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RASL12
4631404I11Rik
RAS-like, family 12
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Mol Cell Proteomics Feb. 01, 2014; 13(2);489-502 [Pubmed: 24319055]
Throughput
- Low Throughput
Additional Notes
- Lumier screen
Curated By
- BioGRID