ACVRL1
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- activin receptor signaling pathway [ISO]
- angiogenesis [IMP, ISO]
- artery development [IMP]
- blood circulation [ISO]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- cellular response to BMP stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- endothelial cell activation [TAS]
- endothelial tube morphogenesis [ISO]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP, ISO]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell adhesion [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell differentiation [IDA]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of focal adhesion assembly [ISO]
- positive regulation of BMP signaling pathway [IDA, ISO]
- positive regulation of angiogenesis [IGI]
- positive regulation of endothelial cell differentiation [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [ISO]
- regulation of blood pressure [ISO]
- regulation of transcription, DNA-templated [ISO]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- signal transduction by phosphorylation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- venous blood vessel development [IMP]
- wound healing, spreading of epidermal cells [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [ISO]
- activin receptor activity, type I [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
Gene Ontology Cellular Component
PPP2CA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACVRL1 PPP2CA | Affinity Capture-Luminescence Affinity Capture-Luminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag. | Low | - | BioGRID | 3463039 |
Curated By
- BioGRID