NOS3
Gene Ontology Biological Process
- angiogenesis [IMP]
- arginine catabolic process [ISO]
- blood vessel remodeling [IMP]
- cellular response to mechanical stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- endothelial cell migration [ISO]
- in utero embryonic development [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- lung development [IMP]
- negative regulation of blood pressure [IBA]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of hydrolase activity [IMP]
- negative regulation of muscle hyperplasia [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of smooth muscle cell proliferation [ISO]
- nitric oxide biosynthetic process [IMP, ISO]
- nitric oxide mediated signal transduction [IBA]
- ovulation from ovarian follicle [IMP]
- oxidation-reduction process [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of guanylate cyclase activity [IBA, ISO]
- positive regulation of vasodilation [IBA]
- regulation of blood vessel size [IMP]
- regulation of sodium ion transport [IMP]
- regulation of systemic arterial blood pressure by endothelin [ISO]
- regulation of the force of heart contraction by chemical signal [IGI]
- response to estradiol [ISO]
- signal transduction [ISO]
- smooth muscle hyperplasia [IMP]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- actin monomer binding [ISO]
- arginine binding [ISO]
- beta-catenin binding [ISO]
- cadherin binding [ISO]
- calmodulin binding [ISO]
- heme binding [ISO]
- nitric-oxide synthase activity [IMP, ISO]
- nitric-oxide synthase binding [ISO]
- scaffold protein binding [ISO]
- tetrahydrobiopterin binding [ISO]
- Hsp90 protein binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- actin binding [ISO]
- actin monomer binding [ISO]
- arginine binding [ISO]
- beta-catenin binding [ISO]
- cadherin binding [ISO]
- calmodulin binding [ISO]
- heme binding [ISO]
- nitric-oxide synthase activity [IMP, ISO]
- nitric-oxide synthase binding [ISO]
- scaffold protein binding [ISO]
- tetrahydrobiopterin binding [ISO]
Gene Ontology Cellular Component
PPP2CA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID