BAIT
PPP2CA
PP2A, R75353, RP23-46N3.2
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
GO Process (19)
GO Function (15)
GO Component (9)
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
ENG
AI528660, AI662476, CD105, Endo, S-endoglin, RP23-17P12.4
endoglin
GO Process (38)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- angiogenesis [IMP]
- artery morphogenesis [IMP]
- cell chemotaxis [ISO]
- cell migration [ISO]
- cell migration involved in endocardial cushion formation [IMP]
- cell motility [ISO]
- central nervous system vasculogenesis [ISO]
- detection of hypoxia [ISO]
- extracellular matrix constituent secretion [ISO]
- extracellular matrix disassembly [ISO]
- heart development [IMP]
- heart looping [IMP]
- intracellular signal transduction [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of nitric-oxide synthase activity [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of protein autophosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- patterning of blood vessels [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [IGI, TAS]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of systemic arterial blood pressure [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [ISO]
- regulation of transcription, DNA-templated [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO, TAS]
- response to hypoxia [ISO]
- smooth muscle tissue development [IMP]
- transforming growth factor beta receptor signaling pathway [IC]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vasculogenesis [IMP, ISO]
- venous blood vessel morphogenesis [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- galactose binding [ISO]
- glycosaminoglycan binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IPI, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor, cytoplasmic mediator activity [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [ISO]
- galactose binding [ISO]
- glycosaminoglycan binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IPI, ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor, cytoplasmic mediator activity [ISO]
- transforming growth factor beta-activated receptor activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type II transforming growth factor beta receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.
Endoglin and activin receptor-like kinase 1 are specialized transforming growth factor-beta (TGF-?) superfamily receptors, primarily expressed in endothelial cells. Mutations in the corresponding ENG or ACVRL1 genes lead to hereditary hemorrhagic telangiectasia (HHT1 and HHT2 respectively). To discover proteins interacting with endoglin, ACVRL1 and TGF-? receptor type 2 and involved in TGF-? signaling, we applied LUMIER, a high-throughput mammalian interactome ... [more]
Mol Cell Proteomics Feb. 01, 2014; 13(2);489-502 [Pubmed: 24319055]
Throughput
- Low Throughput
Curated By
- BioGRID