BAIT
PARK2
AR-JP, LPRS2, PDJ, PRKN, KB-152G3.1
parkin RBR E3 ubiquitin protein ligase
GO Process (58)
GO Function (22)
GO Component (12)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SIRT2
SIR2, SIR2L, SIR2L2
sirtuin 2
GO Process (50)
GO Function (15)
GO Component (22)
Gene Ontology Biological Process
- cellular lipid catabolic process [ISS]
- cellular response to caloric restriction [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to hepatocyte growth factor stimulus [IDA]
- cellular response to hypoxia [IDA]
- cellular response to molecule of bacterial origin [IDA]
- cellular response to oxidative stress [ISS]
- chromatin silencing [NAS]
- chromatin silencing at rDNA [NAS]
- chromatin silencing at telomere [NAS]
- gene silencing [NAS]
- hepatocyte growth factor receptor signaling pathway [IDA]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA, TAS]
- myelination in peripheral nervous system [ISS]
- negative regulation of autophagy [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of defense response to bacterium [IMP]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of oligodendrocyte progenitor proliferation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of reactive oxygen species metabolic process [ISS]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-lysine deacetylation [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of DNA binding [ISS]
- positive regulation of attachment of spindle microtubules to kinetochore [ISS]
- positive regulation of cell division [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- positive regulation of meiosis [ISS]
- positive regulation of oocyte maturation [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ADP-ribosylation [NAS, TAS]
- protein deacetylation [IDA, IMP]
- protein kinase B signaling [IMP]
- regulation of cell cycle [IMP]
- regulation of exit from mitosis [NAS]
- regulation of myelination [ISS]
- regulation of phosphorylation [NAS]
- response to redox state [NAS]
- substantia nigra development [IEP]
- tubulin deacetylation [IDA, IMP, ISS]
Gene Ontology Molecular Function- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- chromatin binding [IDA]
- histone acetyltransferase binding [IPI]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- transcription factor binding [IPI]
- tubulin deacetylase activity [IDA]
- ubiquitin binding [IDA]
- zinc ion binding [IDA]
- NAD+ ADP-ribosyltransferase activity [TAS]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, IMP]
- chromatin binding [IDA]
- histone acetyltransferase binding [IPI]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- transcription factor binding [IPI]
- tubulin deacetylase activity [IDA]
- ubiquitin binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [ISS]
- centriole [IDA]
- centrosome [IDA]
- chromatin silencing complex [NAS]
- chromosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- glial cell projection [ISS]
- juxtaparanode region of axon [ISS]
- lateral loop [ISS]
- meiotic spindle [ISS]
- microtubule [IDA]
- midbody [IDA]
- mitotic spindle [IDA]
- myelin sheath [ISS]
- nuclear heterochromatin [ISS]
- nucleus [IDA]
- paranodal junction [ISS]
- paranode region of axon [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [ISS]
- spindle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences mitophagy level, but the underlying mechanism is poorly understood. Here, our study demonstrated that inhibition of histone deacetylase (HDAC) by treatment of HDACis activates mitophagy through mediating Parkin acetylation, ... [more]
Acta Pharm Sin B Feb. 01, 2022; 12(2);838-852 [Pubmed: 35256949]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein-protein interactors of PARK2 under SAHA treatment.
Curated By
- BioGRID