BAIT

M

mem, membrane, SARS-CoV2 M, M protein, SARS-CoV-2 M, VME1_SARS2, PRO_0000449652, GU280_gp05
Membrane glycoprotein
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

HOOK3

HK3
hook microtubule-tethering protein 3
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

May DG, Martin-Sancho L, Anschau V, Liu S, Chrisopulos RJ, Scott KL, Halfmann CT, Diaz Pena R, Pratt D, Campos AR, Roux KJ

The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global proteomic analysis, and proximity ... [more]

Viruses Dec. 15, 2021; 14(3); [Pubmed: 35337019]

Throughput

  • High Throughput

Additional Notes

  • BioID system
  • Significant viral-host BioID protein interaction with a log2FC >= 2.3, p value =< 0.01, at least two quantitative peptide features, and detected in less than 50% of the proximity-labeling CRAPome contaminant database experiments.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
M HOOK3
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High1.49BioGRID
2791372

Curated By

  • BioGRID