MEN1
Gene Ontology Biological Process
- DNA repair [NAS]
- MAPK cascade [IDA]
- cellular response to DNA damage stimulus [IDA]
- gene expression [TAS]
- histone lysine methylation [IDA]
- negative regulation of JNK cascade [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of telomerase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- osteoblast development [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to UV [IDA]
- response to gamma radiation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INO80
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA]
- UV-damage excision repair [IMP]
- cellular response to UV [IMP]
- cellular response to ionizing radiation [IMP]
- chromatin remodeling [IDA]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- mitotic sister chromatid segregation [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- spindle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.
Targeting vulnerabilities of cancer cells by inhibiting key regulators of cell proliferation or survival represents a promising way to overcome resistance to current therapies. In breast cancer (BC), resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor alpha (ER?) signaling to the genome. Targeting components of the ER? pathway in these tumors represents, therefore, a rational way ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INO80 MEN1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -1.0446 | BioGRID | 2537735 |
Curated By
- BioGRID