BAIT
MEN1
MEAI, SCG2
multiple endocrine neoplasia I
GO Process (24)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- DNA repair [NAS]
- MAPK cascade [IDA]
- cellular response to DNA damage stimulus [IDA]
- gene expression [TAS]
- histone lysine methylation [IDA]
- negative regulation of JNK cascade [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of telomerase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- osteoblast development [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to UV [IDA]
- response to gamma radiation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TFRC
CD71, T9, TFR, TFR1, TR, TRFR, p90
transferrin receptor
GO Process (6)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.
Targeting vulnerabilities of cancer cells by inhibiting key regulators of cell proliferation or survival represents a promising way to overcome resistance to current therapies. In breast cancer (BC), resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor alpha (ER?) signaling to the genome. Targeting components of the ER? pathway in these tumors represents, therefore, a rational way ... [more]
Breast Cancer Res Dec. 18, 2021; 24(1);52 [Pubmed: 35850772]
Throughput
- Low Throughput
Curated By
- BioGRID