BAIT

PLEKHA5

PEPP-2, PEPP2
pleckstrin homology domain containing, family A member 5
GO Process (0)
GO Function (2)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

COPB2

beta'-COP
coatomer protein complex, subunit beta 2 (beta prime)
GO Process (4)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.

Cao X, Shami Shah A, Sanford EJ, Smolka MB, Baskin JM

The anaphase-promoting complex/cyclosome (APC/C) coordinates advancement through mitosis via temporally controlled polyubiquitination events. Despite the long-appreciated spatial organization of key events in mitosis mediated largely by cytoskeletal networks, the spatial regulation of APC/C, the major mitotic E3 ligase, is poorly understood. We describe a microtubule-resident protein, PLEKHA5, as an interactor of APC/C and spatial regulator of its activity in mitosis. ... [more]

ACS Chem Biol Sep. 16, 2022; 17(9);2605-2618 [Pubmed: 35952650]

Throughput

  • High Throughput

Curated By

  • BioGRID