An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TRIM24 is an insulin-responsive regulator of P-bodies.

Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S

Insulin is a potent inducer of mRNA transcription and translation, contributing to metabolic regulation. Insulin has also been suggested to regulate mRNA stability through the processing body (P-body) molecular machinery. However, whether and how insulin regulates mRNA stability via P-bodies is not clear. Here we show that the E3-ligase TRIM24 is a critical factor linking insulin signalling to P-bodies. Upon ... [more]

Nat Commun Dec. 08, 2021; 13(1);3972 [Pubmed: 35803934]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

TRIM24

Gene Ontology Biological Process

Gene Ontology Molecular Function

chromatin binding [IDA]estrogen response element binding [IDA]lysine-acetylated histone binding [IDA]methylated histone binding [IDA]p53 binding [IPI]protein binding [IPI]receptor binding [TAS]transcription coactivator activity [IDA]ubiquitin-protein transferase activity [IDA]zinc ion binding [IDA]

Gene Ontology Cellular Component

SLC25A6