TRIM24
Gene Ontology Biological Process
- calcium ion homeostasis [IMP]
- cellular response to estrogen stimulus [ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of gene expression [IGI, IMP]
- positive regulation of transcription, DNA-templated [IGI]
- protein autophosphorylation [IDA]
- protein catabolic process [IMP, ISO]
- protein phosphorylation [IDA]
- protein ubiquitination [IDA, ISO]
- regulation of apoptotic process [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of protein stability [IMP, ISO]
- regulation of signal transduction by p53 class mediator [IGI]
- regulation of vitamin D receptor signaling pathway [IMP]
Gene Ontology Molecular Function- chromatin binding [IDA, ISO]
- estrogen response element binding [ISO]
- ligand-dependent nuclear receptor binding [IDA]
- lysine-acetylated histone binding [ISO]
- p53 binding [IPI, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA, ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
- chromatin binding [IDA, ISO]
- estrogen response element binding [ISO]
- ligand-dependent nuclear receptor binding [IDA]
- lysine-acetylated histone binding [ISO]
- p53 binding [IPI, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA, ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
DDX6
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRIM24 is an insulin-responsive regulator of P-bodies.
Insulin is a potent inducer of mRNA transcription and translation, contributing to metabolic regulation. Insulin has also been suggested to regulate mRNA stability through the processing body (P-body) molecular machinery. However, whether and how insulin regulates mRNA stability via P-bodies is not clear. Here we show that the E3-ligase TRIM24 is a critical factor linking insulin signalling to P-bodies. Upon ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID