BAIT
ZRANB1
TRABID, RP11-298J20.4
zinc finger, RAN-binding domain containing 1
GO Process (8)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- cell migration [IMP]
- cytoskeleton organization [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- protein K29-linked deubiquitination [IDA]
- protein K33-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA, IMP]
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of cell morphogenesis [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
PLCB1
EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B, RP4-654A7.1
phospholipase C, beta 1 (phosphoinositide-specific)
GO Process (29)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- G2/M transition of mitotic cell cycle [ISS]
- activation of meiosis involved in egg activation [ISS]
- cerebral cortex development [ISS]
- glutamate receptor signaling pathway [ISS]
- inositol phosphate metabolic process [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IDA]
- interleukin-12-mediated signaling pathway [IDA]
- interleukin-15-mediated signaling pathway [IDA]
- memory [ISS]
- negative regulation of monocyte extravasation [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol metabolic process [ISS]
- positive regulation of CD24 biosynthetic process [ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of acrosome reaction [ISS]
- positive regulation of developmental growth [ISS]
- positive regulation of embryonic development [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISS]
- regulation of fertilization [ISS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells.
TRAF-binding domain-containing protein (TRABID), a member of the OTU deubiquitinase family, has an important role in regulating cellular functions via deubiquitinating substrate proteins such as EZH2 and Jmjd2d. However, the mechanism of its role in the proliferation of hepatocellular carcinoma (HCC) cells has not been fully elucidated. Here, we analyzed the interactome of TRABID in HepG2 cells through mass spectrometry-based ... [more]
Biochem Biophys Res Commun Dec. 15, 2021; 625();23-30 [Pubmed: 35944360]
Throughput
- Low Throughput
Curated By
- BioGRID