BAIT
SNCA
NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- calcium ion homeostasis [IDA]
- cellular response to copper ion [IDA]
- cellular response to epinephrine stimulus [TAS]
- cellular response to oxidative stress [IC]
- dopamine biosynthetic process [TAS]
- dopamine uptake involved in synaptic transmission [TAS]
- extracellular fibril organization [TAS]
- microglial cell activation [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [IDA]
- negative regulation of exocytosis [IMP]
- negative regulation of histone acetylation [IDA]
- negative regulation of microtubule polymerization [IDA]
- negative regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- negative regulation of monooxygenase activity [IDA]
- negative regulation of norepinephrine uptake [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of serotonin uptake [IDA]
- negative regulation of thrombin receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transporter activity [IDA]
- oxidation-reduction process [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of endocytosis [IDA]
- positive regulation of glutathione peroxidase activity [IDA]
- positive regulation of hydrogen peroxide catabolic process [IDA]
- positive regulation of inositol phosphate biosynthetic process [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of receptor recycling [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein destabilization [IDA]
- receptor internalization [IDA]
- regulation of dopamine secretion [TAS]
- regulation of phospholipase activity [IDA]
- regulation of reactive oxygen species biosynthetic process [TAS]
- regulation of synaptic vesicle recycling [TAS]
- response to interferon-gamma [IDA]
- response to interleukin-1 [IDA]
- response to iron(II) ion [IDA]
- response to lipopolysaccharide [IDA]
- response to magnesium ion [IDA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular region [TAS]
- fibril [IDA]
- growth cone [IDA]
- inclusion body [IDA]
- lysosome [TAS]
- mitochondrial respiratory chain complex I [TAS]
- mitochondrion [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule membrane [IDA]
Homo sapiens
PREY
HSP90AA1
Hsp86, Hsp90, Hspca
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (16)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The interactome of stabilized ?-synuclein oligomers and neuronal proteins.
While it is generally accepted that ?-synuclein oligomers (?SOs) play an important role in neurodegeneration in Parkinson's disease, the basis for their cytotoxicity remains unclear. We have previously shown that docosahexaenoic acid (DHA) stabilizes ?SOs against dissociation without compromising their ability to colocalize with glutamatergic synapses of primary hippocampal neurons, suggesting that they bind to synaptic proteins. Here, we develop ... [more]
Unknown May. 01, 2020; 287(10);2037-2054 [Pubmed: 31686426]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNCA HSP90AA1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5763 | BioGRID | 3776894 |
Curated By
- BioGRID