BAIT
SNCA
NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- calcium ion homeostasis [IDA]
- cellular response to copper ion [IDA]
- cellular response to epinephrine stimulus [TAS]
- cellular response to oxidative stress [IC]
- dopamine biosynthetic process [TAS]
- dopamine uptake involved in synaptic transmission [TAS]
- extracellular fibril organization [TAS]
- microglial cell activation [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [IDA]
- negative regulation of exocytosis [IMP]
- negative regulation of histone acetylation [IDA]
- negative regulation of microtubule polymerization [IDA]
- negative regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- negative regulation of monooxygenase activity [IDA]
- negative regulation of norepinephrine uptake [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of serotonin uptake [IDA]
- negative regulation of thrombin receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transporter activity [IDA]
- oxidation-reduction process [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of endocytosis [IDA]
- positive regulation of glutathione peroxidase activity [IDA]
- positive regulation of hydrogen peroxide catabolic process [IDA]
- positive regulation of inositol phosphate biosynthetic process [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of receptor recycling [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein destabilization [IDA]
- receptor internalization [IDA]
- regulation of dopamine secretion [TAS]
- regulation of phospholipase activity [IDA]
- regulation of reactive oxygen species biosynthetic process [TAS]
- regulation of synaptic vesicle recycling [TAS]
- response to interferon-gamma [IDA]
- response to interleukin-1 [IDA]
- response to iron(II) ion [IDA]
- response to lipopolysaccharide [IDA]
- response to magnesium ion [IDA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular region [TAS]
- fibril [IDA]
- growth cone [IDA]
- inclusion body [IDA]
- lysosome [TAS]
- mitochondrial respiratory chain complex I [TAS]
- mitochondrion [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule membrane [IDA]
Homo sapiens
PREY
HSPD1
Hsp60, Hspd1-30p
heat shock protein 1 (chaperonin)
GO Process (35)
GO Function (12)
GO Component (23)
Gene Ontology Biological Process
- 'de novo' protein folding [IC]
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [IDA]
- detection of misfolded protein [IDA]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [IDA]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to ATP [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to estrogen [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to lipopolysaccharide [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [IPI]
- lipopolysaccharide binding [ISO]
- misfolded protein binding [IPI]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [IPI]
- lipopolysaccharide binding [ISO]
- misfolded protein binding [IPI]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell surface [IDA, ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial crista [IDA]
- mitochondrial inner membrane [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [ISO]
- plasma membrane [ISO]
- protein complex [ISO, ISS]
- rough endoplasmic reticulum [IDA]
- secretory granule [IDA, ISO]
- zymogen granule [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The interactome of stabilized ?-synuclein oligomers and neuronal proteins.
While it is generally accepted that ?-synuclein oligomers (?SOs) play an important role in neurodegeneration in Parkinson's disease, the basis for their cytotoxicity remains unclear. We have previously shown that docosahexaenoic acid (DHA) stabilizes ?SOs against dissociation without compromising their ability to colocalize with glutamatergic synapses of primary hippocampal neurons, suggesting that they bind to synaptic proteins. Here, we develop ... [more]
Unknown May. 01, 2020; 287(10);2037-2054 [Pubmed: 31686426]
Throughput
- High Throughput
Curated By
- BioGRID