BAIT

SPAG6

PF16

sperm associated antigen 6

GO Process (2)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

sperm motility [IMP]

spermatogenesis [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

microtubule cytoskeleton [ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

MTDH

2610103J23Rik, 3D3, 3D3/Lyric, AEG-1, AV353288, D8Bwg1112e, Lyric

metadherin

GO Process (8)

GO Function (6)

GO Component (10)

Gene Ontology Biological Process

lipopolysaccharide-mediated signaling pathway [ISO]

negative regulation of apoptotic process [ISO]

negative regulation of transcription from RNA polymerase II promoter [ISO]

positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]

positive regulation of NF-kappaB transcription factor activity [ISO]

positive regulation of angiogenesis [ISO]

positive regulation of autophagy [ISO]

positive regulation of protein kinase B signaling [ISO]

Gene Ontology Molecular Function

NF-kappaB binding [ISO]
RNA polymerase II transcription factor binding [ISO]
double-stranded RNA binding [ISO]
poly(A) RNA binding [ISO]
protein binding [IPI]
transcription coactivator activity [ISO]

Gene Ontology Cellular Component

apical plasma membrane [ISO]

cytoplasm [ISO]

endoplasmic reticulum [IDA, ISO]

endoplasmic reticulum membrane [IDA]

intercellular canaliculus [ISO]

nuclear body [ISO]

nucleolus [IDA, ISO]

perinuclear region of cytoplasm [IDA, ISO]

tight junction [ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The sperm-associated antigen 6 interactome and its role in spermatogenesis.

Liu Y, Zhang L, Li W, Huang Q, Yuan S, Li Y, Liu J, Zhang S, Pin G, Song S, Ray PF, Arnoult C, Cho C, Garcia-Reyes B, Knippschild U, Strauss JF, Zhang Z

Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has functions beyond its role in the central apparatus. Hence, we reexamined the role of SPAG6 in male fertility. In wild-type mice, SPAG6 was present in cytoplasmic ... [more]

Reproduction Dec. 01, 2018; 158(2);181-197 [Pubmed: 31146259]

Throughput

High Throughput

Curated By

BioGRID