BAIT
SPAG6
PF16
sperm associated antigen 6
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PFKM
AI131669, ATP-PFK, PFK-A, PFK-M, Pfk-4, Pfk4, Pfka, Pfkx
phosphofructokinase, muscle
GO Process (10)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- carbohydrate phosphorylation [IMP, ISO]
- fructose 1,6-bisphosphate metabolic process [ISO]
- fructose 6-phosphate metabolic process [ISO]
- glucose homeostasis [IMP]
- glycolytic process [IDA, IMP, ISO, ISS]
- glycolytic process through fructose-6-phosphate [IC]
- muscle cell cellular homeostasis [ISO]
- positive regulation of insulin secretion [IMP]
- protein homotetramerization [ISO]
- protein oligomerization [ISO]
Gene Ontology Molecular Function- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- 6-phosphofructokinase activity [IDA, IMP, ISO, ISS]
- AMP binding [ISO]
- ATP binding [ISO]
- carbohydrate binding [ISO]
- fructose binding [ISO]
- fructose-6-phosphate binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IDA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The sperm-associated antigen 6 interactome and its role in spermatogenesis.
Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has functions beyond its role in the central apparatus. Hence, we reexamined the role of SPAG6 in male fertility. In wild-type mice, SPAG6 was present in cytoplasmic ... [more]
Reproduction Dec. 01, 2018; 158(2);181-197 [Pubmed: 31146259]
Throughput
- High Throughput
Curated By
- BioGRID