BAIT
SPAG6
PF16
sperm associated antigen 6
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CADM1
2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Igsf4, Igsf4a, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, ST17, SgIGSF, SynCam, Tslc1
cell adhesion molecule 1
GO Process (13)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- bone development [IMP]
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [IDA]
- cell adhesion [IDA]
- cell recognition [IDA, ISO]
- detection of stimulus [IDA, ISO]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- liver development [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of natural killer cell mediated cytotoxicity [IDA, ISO]
- susceptibility to natural killer cell mediated cytotoxicity [IDA, ISO]
- synapse assembly [IDA]
- unidimensional cell growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The sperm-associated antigen 6 interactome and its role in spermatogenesis.
Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has functions beyond its role in the central apparatus. Hence, we reexamined the role of SPAG6 in male fertility. In wild-type mice, SPAG6 was present in cytoplasmic ... [more]
Reproduction Dec. 01, 2018; 158(2);181-197 [Pubmed: 31146259]
Throughput
- High Throughput
Curated By
- BioGRID