BAIT
SPAG6
PF16
sperm associated antigen 6
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SRI
2210417O06Rik, 2900070H08Rik, Sor
sorcin
GO Process (13)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- calcium ion transport [IPI]
- cytoplasmic sequestering of transcription factor [IMP]
- negative regulation of heart rate [ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- negative regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- proteolysis [IBA]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of cell communication by electrical coupling involved in cardiac conduction [ISO]
- regulation of high voltage-gated calcium channel activity [ISO]
- regulation of relaxation of muscle [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- Z disc [IDA, ISO]
- axon [ISO]
- axon terminus [ISO]
- cell [IMP]
- chromaffin granule membrane [ISO]
- cytoplasm [IMP, ISO]
- cytosol [ISO]
- dendritic spine neck [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- nucleoplasm [ISO]
- plasma membrane [IDA, ISO]
- smooth endoplasmic reticulum [ISO]
- vesicle [IDA]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The sperm-associated antigen 6 interactome and its role in spermatogenesis.
Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has functions beyond its role in the central apparatus. Hence, we reexamined the role of SPAG6 in male fertility. In wild-type mice, SPAG6 was present in cytoplasmic ... [more]
Reproduction Dec. 01, 2018; 158(2);181-197 [Pubmed: 31146259]
Throughput
- High Throughput
Curated By
- BioGRID