BBS4
Gene Ontology Biological Process
- adult behavior [IMP]
- brain morphogenesis [IMP]
- centrosome organization [ISO]
- cerebral cortex development [IMP]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- dendrite development [IMP]
- hippocampus development [IMP]
- leptin-mediated signaling pathway [IMP]
- maintenance of protein location in nucleus [ISO]
- metabolic process [ISO]
- microtubule anchoring at centrosome [ISO]
- microtubule cytoskeleton organization [IMP]
- mitotic cytokinesis [ISO]
- negative regulation of appetite by leptin-mediated signaling pathway [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- neural tube closure [IMP]
- nonmotile primary cilium assembly [IMP]
- photoreceptor cell maintenance [IMP]
- positive regulation of cilium assembly [IMP]
- positive regulation of multicellular organism growth [IMP]
- protein localization [IMP]
- protein localization to centrosome [ISO]
- protein localization to organelle [IDA]
- regulation of cilium beat frequency involved in ciliary motility [IMP]
- regulation of cytokinesis [ISO]
- regulation of lipid metabolic process [IMP]
- response to leptin [IMP]
- retina homeostasis [IMP]
- retinal rod cell development [IMP]
- sensory perception of smell [IMP]
- spermatid development [IMP]
- striatum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPAG6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The sperm-associated antigen 6 interactome and its role in spermatogenesis.
Mammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, including sperm motility. Recent studies revealed that SPAG6 has functions beyond its role in the central apparatus. Hence, we reexamined the role of SPAG6 in male fertility. In wild-type mice, SPAG6 was present in cytoplasmic ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SPAG6 BBS4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low/High | - | BioGRID | - |
Curated By
- BioGRID